Collagen matrix containing cultured autologous chondrocytes (development code: IK-01) is a product produced from cells collected from the patient’s own cartilage tissue of the knee joint and then seeded and cultured in a collagen gel. This product features the ability to realize a simple surgical procedure by using a collagen matrix having a reasonable strength as a 3D-scaffold. An investigator-initiated trial with IK-01 was conducted in 2012 in subjects with traumatic knee cartilage damage at the Department of Orthopaedic Surgery, Kove University School of Medicine, and at the Foundation for Biomedical Research and Innovation at Kobe (FBRI). We originally entered into a joint development agreement for IK-01 with FBRI in 2015, and a confirmatory trial was started in 2018, mainly at Department of Orthopaedic Surgery, Kove University School of Medicine, and Department of Orthopaedic Surgery, Hirosaki University School of Medicine, and has been completed. In addition, more recently, a clinical study in subjects with knee osteoarthritis has been undertaken.